Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability.
Voltage-gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neurons.Na(V)1.8 is a tetrodotoxin (TTX) resistant VGSC expressed in nociceptors, peripheral small-diameter neurons able to detect noxious stimuli.Na(V)1.8 underlies the vast majority of sodium currents during action potentials.Many studi